Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease.

Abstract

AIM:

To evaluate roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease (IPSID) and to study profiles of kappa (kappa) and lambda (lambda) light chains and IgA heavy chain.

METHODS:

The study consisted of 11 cases of IPSID and similar number of controls which included 11 of normal intestinal mucosa and 11 of high grade B cell lymphoma of ileum. The parameters analyzed included clinical profiles, biochemical and other laboratory investigations, radiologic and histological findings including immunohistochemistry.

RESULTS:

All IPSID cases had demonstrable serum IgA heavy chain and heavy mucosal plasma cell infiltration. According to Galian's histological staging, there were 4 patients with stage A and 7 with stage B. kappa and lambda light chains were over-expressed in 7 patients; 1 stage A patient had H pylori-positive active gastritis and eradication of H pylori led to disease remission. Stage A biopsies had higher expression for syndecan-1, while stage B had higher expression for bcl6 and p53. Syndecan-1, kappa and lambda light chains and IgA heavy chain showed inverse relationship with bcl6 and p53. All patients were treated with doxycycline. CHOP regime was added in 5 patients who developed frank lymphoma. Three died of the disease due to extensive organ infiltration.

CONCLUSION:

Certain immunomarkers like syndecan-1, kappa and lambda light chains and IgA heavy chain could be of much help in identifying early stage IPSID. Stage B IPSID showed higher expression for bcl6 and p53 than stage A IPSID. bcl6 and p53 expressions correlated with a more advanced disease stage and aggressive tumour behavior.

• Authors: Kim Vaiphei, Neeraj Kumari, Saroj-Kant Sinha, Usha Dutta, Birinder Nagi, Kusum Joshi, Kartar Singh
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 12 Issue 22 Pg. 3602-8 (Jun 14 2006) ISSN: 1007-9327 [Print] United States
• PMID: 16773719 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• BCL6 protein, human
• DNA-Binding Proteins
• Immunoglobulin alpha-Chains
• Immunoglobulin kappa-Chains
• Immunoglobulin lambda-Chains
• Membrane Glycoproteins
• Proteoglycans
• Proto-Oncogene Proteins c-bcl-6
• SDC1 protein, human
• Syndecan-1
• Syndecans
• Tumor Suppressor Protein p53
• Doxycycline

Topics

• Adult
• Anti-Bacterial Agents (therapeutic use)
• Case-Control Studies
• DNA-Binding Proteins (analysis, genetics, immunology)
• Disease Progression
• Doxycycline (therapeutic use)
• Endoscopy, Gastrointestinal
• Female
• Gene Expression Regulation
• Helicobacter pylori
• Humans
• Immunoglobulin alpha-Chains (blood, genetics)
• Immunoglobulin kappa-Chains (analysis, genetics)
• Immunoglobulin lambda-Chains (analysis, genetics)
• Immunohistochemistry
• Immunoproliferative Small Intestinal Disease (diagnosis, drug therapy, genetics, immunology)
• Intestinal Mucosa (chemistry, microbiology, pathology)
• Intestine, Small (chemistry, microbiology, pathology)
• Male
• Membrane Glycoproteins (analysis, genetics, immunology)
• Middle Aged
• Prognosis
• Proteoglycans (analysis, genetics, immunology)
• Proto-Oncogene Proteins c-bcl-6
• Syndecan-1
• Syndecans
• Tumor Suppressor Protein p53 (analysis, genetics, immunology)