Abstract | OBJECTIVES: Gamma knife radiosurgery as a noninvasive procedure is increasingly used as a treatment option in patients with intractable seizures. We investigated efficacy and safety of gamma knife radiosurgery (GKRS) for callosotomy in children. MATERIALS AND METHODS: Between 2000 and 2004 three children between 4 and 14 years (mean 8 years) underwent radiosurgical callosotomy. One child presented with Lennox-Gastaut syndrome, two with hemispheric cortical dysplasia. These two children underwent functional hemispherotomy before GKRS. GKRS was performed with a marginal dose of 55-60 Gy on the 50% isodose. RESULTS: Mean follow-up was 35 months. Radiosurgical callosotomy was ineffective in one child with the Lennox-Gastaut syndrome, whereas in the remaining two children, a 100% seizure reduction of generalized tonic-clonic seizures, 20-70% reduction of partial seizures, and a progress in mental and physical development was achieved. No postradiosurgical side effects were observed in all children. CONCLUSION: Radiosurgical callosotomy might be offered after hemispherotomy to complete callosal resection. However, larger number of patients and longer follow-ups are needed to draw final conclusions.
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Authors | Hans Georg Eder, Michael Feichtinger, Tom Pieper, Senta Kurschel, Oskar Schroettner |
Journal | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
(Childs Nerv Syst)
Vol. 22
Issue 8
Pg. 1012-7
(Aug 2006)
ISSN: 0256-7040 [Print] Germany |
PMID | 16770617
(Publication Type: Evaluation Study, Journal Article)
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Topics |
- Adolescent
- Child
- Child, Preschool
- Corpus Callosum
(surgery)
- Drug Resistance
- Epilepsy
(drug therapy, pathology, surgery)
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Radiosurgery
(methods)
- Retrospective Studies
- Treatment Outcome
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