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Ostene, a new water-soluble bone hemostasis agent.

Abstract
Traditional formulations of bone wax are composed largely of beeswax and are well known to interfere with bone healing and cause inflammatory reactions. Ostene, a newly available bone hemostasis agent made of water-soluble alkylene oxide copolymers, was evaluated. The soft tissue response to Ostene was compared with bone wax and a polyethylene control after implantation into the paravertebral muscles of three rabbits. After 2 weeks, Ostene elicited no fibrous response, the polyethylene elicited a thin (less than 0.5 mm) fibrous response, and the bone wax was encased in a fibrous capsule 0.6 to 1.0 mm thick infiltrated with inflammatory cells. The effects of Ostene were compared with bone wax in a femur defect model in eight rabbits. Ostene showed no evidence of an adverse response in the cortical defect site, medullary cavity, or the surrounding tissue at 4 and 8 weeks. In contrast, bone wax at both time intervals elicited a foreign body response consisting of fibrous tissue infiltrated by macrophages, giant cells, and lymphocytes at the sites of the bone defects. Bone wax also displaced the bone marrow and interfered with bone ingrowth into the defects. Ostene provides the clinician a water-soluble bone hemostasis material that does not demonstrate the adverse tissue response or the interference with bone healing seen with the use of bone wax.
AuthorsTadeusz Wellisz, Jonathan K Armstrong, John Cambridge, Timothy C Fisher
JournalThe Journal of craniofacial surgery (J Craniofac Surg) Vol. 17 Issue 3 Pg. 420-5 (May 2006) ISSN: 1049-2275 [Print] United States
PMID16770175 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Drug Combinations
  • Hemostatics
  • Ostene
  • Palmitates
  • Polymers
  • Waxes
  • Water
  • Poloxamer
  • bone wax
  • Polyethylene
Topics
  • Animals
  • Connective Tissue (pathology)
  • Drug Combinations
  • Female
  • Femur (pathology, surgery)
  • Foreign-Body Reaction (etiology)
  • Giant Cells (pathology)
  • Hemostatics (chemistry, therapeutic use)
  • Lymphocytes (pathology)
  • Macrophages (pathology)
  • Muscle, Skeletal (pathology, surgery)
  • Osteogenesis (physiology)
  • Palmitates (therapeutic use)
  • Poloxamer (chemistry, therapeutic use)
  • Polyethylene (therapeutic use)
  • Polymers (chemistry, therapeutic use)
  • Rabbits
  • Solubility
  • Time Factors
  • Water
  • Waxes (therapeutic use)
  • Wound Healing (physiology)

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