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A locus on the long arm of chromosome 1 as a possible cause of essential hypertension.

Abstract
1. None of the genes responsible for essential hypertension has been identified. Recent work in genetically hypertensive rats has shown linkage of blood pressure with alleles of the renin gene. Since the renin gene is a member of a conserved synteny group that in humans spans chromosome 1q21.3-32.3 and includes the gene for antithrombin III (AT3), we used linkage studies to examine the relationship between alleles of AT3 and hypertension in a family having 10 affected members. 2. From the lod score obtained at a recombination fraction of zero the odds for linkage of AT3 and hypertension in this family were calculated as 6:1 in favour of linkage. This result provides grounds for further examination of the possible role of the 1q23 locus in the aetiology of essential hypertension.
AuthorsL R Griffiths, R Y Zee, L H Ying, B J Morris
JournalClinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol) Vol. 18 Issue 5 Pg. 363-6 (May 1991) ISSN: 0305-1870 [Print] Australia
PMID1676620 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antithrombin III
Topics
  • Antithrombin III (genetics, physiology)
  • Blotting, Southern
  • Chromosomes, Human, Pair 1 (physiology)
  • Family Health
  • Genetic Linkage (genetics)
  • Humans
  • Hypertension (genetics)
  • Polymorphism, Restriction Fragment Length

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