HLA associations with Hashimoto's thyroiditis.

Abstract

There is disagreement over the HLA-DR associations of Hashimoto's (goitrous) thyroiditis. We have studied 86 English Caucasian patients with this condition whose DR types were determined by restriction fragment polymorphism analysis. HLA-DR3 was significantly more frequent in these patients than in 100 controls (chi 2 = 7.09; P less than 0.01). The relative risk was 2.23 and aetiological fraction 0.29. HLA-DPB and DQB alleles were analysed in a proportion of these subjects by enzymatic DNA amplification and oligonucleotide probing. The only significant finding was an excess of HLA-DQw2 (in linkage disequilibrium with DR3) in the Hashimoto group (chi 2 = 7.43, P less than 0.007). These results do not support a difference between goitrous and atrophic thyroiditis based on respective associations with HLA-DR5 and DR3, but confirm a recent study in which HLA-DR3 was associated with Hashimoto's thyroiditis. However, it is possible that genes telomeric to DR3 may be involved in determining which type of thyroiditis a patient with autoimmune hypothyroidism develops.

• Authors: N Tandon, L Zhang, A P Weetman
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 34 Issue 5 Pg. 383-6 (May 1991) ISSN: 0300-0664 [Print] England
• PMID: 1676351 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-D Antigens
• HLA-DQ Antigens
• HLA-DQ2 antigen
• HLA-DR3 Antigen

Topics

• Female
• HLA-D Antigens (analysis)
• HLA-DQ Antigens (analysis)
• HLA-DR3 Antigen (analysis)
• Humans
• Linkage Disequilibrium (genetics)
• Male
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Thyroiditis, Autoimmune (genetics)