Correlating toxicities of organic compounds to select protozoa using the Abraham model.

Abstract

The Abraham solvation parameter model is used to construct mathematical correlations for describing the nonspecific toxicity of organic compounds to three protozoas (Entosiphon sulcantum, Uronema parduczi and Chilomonas paramecium). The derived mathematical correlations describe the observed published toxicity data to within an overall average standard deviation of approximately 0.35 log units. The correlations can be used to estimate aquatic toxicities of organic chemicals to the three aquatic organisms studied, and to help in identifying compounds whose toxic mode of action might involve chemical specific reactivity, rather than nonpolar or polar narcosis. A principal component analysis of the correlation equations found in this work shows that no water-solvent system we have investigated is a good model for nonspecific aquatic toxicity towards the three protozoas. Furthermore, correlation equations for nonspecific aqueous toxicity towards various biological systems, that we have found in this work and in previous studies, cover such a wide range that no single water-solvent system could ever be a good model for all the biological systems.

• Authors: Kaci R Bowen, Kelly B Flanagan, William E Acree Jr, Michael H Abraham
• Journal: The Science of the total environment (Sci Total Environ) Vol. 369 Issue 1-3 Pg. 109-18 (Oct 01 2006) ISSN: 0048-9697 [Print] Netherlands
• PMID: 16759684 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Organic Chemicals
• Water Pollutants, Chemical

Topics

• Animals
• Ciliophora (drug effects, growth & development)
• Cryptophyta (drug effects, growth & development)
• Euglenida (drug effects, growth & development)
• Models, Biological
• Organic Chemicals (toxicity)
• Principal Component Analysis
• Water Pollutants, Chemical (toxicity)