Abstract | BACKGROUND: PI3K/Akt pathway has been shown to play a critical role in the regulation of mitogenic signalling, apoptosis, cell proliferation and survival in a variety of cells and tissues. The aim of the present study was to investigate the role of PI3K/Akt pathway in the renal ischaemia/reperfusion. METHODS: RESULTS: CONCLUSION: This primary study suggests that PI3-kinase/Akt signalling pathway play an important role in the regulation of the renal repair after ischaemia/ reperfusion injury.
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Authors | Liping Xie, Xiangyi Zheng, Jie Qin, Zhaodian Chen, Yongfeng Jin, Wei Ding |
Journal | Nephrology (Carlton, Vic.)
(Nephrology (Carlton))
Vol. 11
Issue 3
Pg. 207-12
(Jun 2006)
ISSN: 1320-5358 [Print] Australia |
PMID | 16756633
(Publication Type: Journal Article)
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Chemical References |
- Phosphatidylinositol 3-Kinases
- Proto-Oncogene Proteins c-akt
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Topics |
- Animals
- Blood Urea Nitrogen
- Cell Proliferation
- Cell Shape
- Kidney
(pathology, physiology)
- Kidney Diseases
(blood, enzymology, pathology)
- Male
- Mice
- Mice, Inbred BALB C
- Phosphatidylinositol 3-Kinases
(metabolism)
- Phosphorylation
- Proto-Oncogene Proteins c-akt
(metabolism)
- Reperfusion Injury
(blood, enzymology, pathology)
- Signal Transduction
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