[In vitro effects of antiviral drugs on the reproduction of highly pathogenic influenza A/H5N1 virus strains that induce epizooty among poultry in the summer of 2005].

Abstract

Commercial drugs, such as rimantadine, amantadine, rivabirine, and arbidole, are effective in suppressing the in vitro reproduction of highly pathogenic avian influenza A/H5N1 viruses. The study has used a porcine embryonic renal cell line and the highly pathogenic A/Duck/Novosibirsk/56/05 (H5N1) strain from a sick domestic duck (Anas platyrhynchos domesticus) (Chany Lake environs, Novosibirsk Region).

• Authors: D K L'vov, I T Fediakina, M Iu Shchelkanov, A G Prilipov, P G Deriabin, G A Galegov
• Journal: Voprosy virusologii (Vopr Virusol) 2006 Mar-Apr Vol. 51 Issue 2 Pg. 20-2 ISSN: 0507-4088 [Print] Russia (Federation)
• PMID: 16756173 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Indoles
• Rimantadine
• Ribavirin
• umifenovir
• Amantadine

Topics

• Amantadine (pharmacology)
• Animals
• Animals, Domestic
• Antiviral Agents (pharmacology)
• Cell Line
• Disease Outbreaks
• Dose-Response Relationship, Drug
• Ducks
• Indoles (pharmacology)
• Influenza A Virus, H5N1 Subtype (drug effects, physiology)
• Influenza in Birds (epidemiology, virology)
• Kidney
• Microbial Sensitivity Tests
• Poultry
• Ribavirin (pharmacology)
• Rimantadine (pharmacology)
• Siberia (epidemiology)
• Swine
• Virus Replication (drug effects)