HI-6 in man: efficacy of the oxime in poisoning by organophosphorus insecticides.

Abstract

The efficacy of the oxime HI-6 was studied as a treatment for organophosphorus poisoning. HI-6 was given four times daily as a single intramuscular injection of 500 mg accompanied by atropine and diazepam therapy. Oxime treatment was started on admission and continued for a minimum of 48 h and a maximum of 7 d. HI-6 rapidly reactivated human blood acetylcholinesterase inhibited by dimethoxy organophosphorus compounds, while the dimethoxy-inhibited enzyme was mainly resistant to the treatment by HI-6. Although both HI-6 and pralidoxime chloride reactivated the red blood cell cholinesterase in quinalphos-poisoned subjects, the return of enzyme activities was more rapid following the use of HI-6. The general improvement of poisoned patients, which was sometimes more rapid than the rise of acetylcholinesterase activity, pointed to direct pharmacological effects of HI-6. No undesirable side-effects were noted in patients when HI-6 plasma concentrations were maintained at levels far above the 'therapeutic' concentration for up to 7 d.

• Authors: R Kusić, D Jovanović, S Randjelović, D Joksović, V Todorovic, B Bosković, M Jokanović, V Vojvodić
• Journal: Human & experimental toxicology (Hum Exp Toxicol) Vol. 10 Issue 2 Pg. 113-8 (Mar 1991) ISSN: 0960-3271 [Print] England
• PMID: 1675101 (Publication Type: Journal Article)

Chemical References

• Antidotes
• Cholinesterase Reactivators
• Insecticides
• Organophosphorus Compounds
• Oximes
• Pyridinium Compounds
• Cholinesterases
• asoxime chloride

Topics

• Adult
• Antidotes (therapeutic use)
• Cholinesterase Reactivators (blood, therapeutic use)
• Cholinesterases (blood)
• Female
• Humans
• Insecticides (poisoning)
• Male
• Organophosphorus Compounds
• Oximes (blood, therapeutic use)
• Poisoning (drug therapy, enzymology)
• Pyridinium Compounds (blood, therapeutic use)