Abstract | UNLABELLED:
Adult-Onset Still's disease (AOSD) is a rare condition of unknown origin with various presentations and unpredictable outcome. The aim of this study was to analyse clinical and biological presentation, and outcome of patients admitted to an internal medicine service. METHOD: A retrospective cohort design with prospective follow-up was used. All the patients admitted to our internal medicine service for AOSD between January 1998 and March 2004 were included. RESULTS: According to Yamaguchi's classification criteria, 17 patients were analysed with a mean age at onset of 37.3 years and a 2.4 sex-ratio (female/male). Mean follow-up length was 52.1 months. Eight patients developed a monocyclic systemic form, 8 a polycyclic systemic form and 1 a chronic articular form. Arthralgia (87%) and arthritis (53%) were less frequent than in other series. Sixteen patients were treated: 14 by corticosteroids, 6 by non- steroid anti-inflammatory drugs, 5 by methotrexate, 2 intravenous polyglobulin and one by anti-TNF drug. Patients with a corticodependant or corticoresistant form had more polyarthritis at the onset of the disease (3/6 vs 0/11, P=0.029). DISCUSSION: In internal medicine activity, AOSD without oligo- or polyarthritis may be more frequent than expected according to the literature. Corticotherapy alone is often efficient in these AOSD form without synovitis, and methotrexate use is uncommon.
|
Authors | T-C Fraisse, F Degraeve, S Rivière, A Le Quellec |
Journal | La Revue de medecine interne
(Rev Med Interne)
Vol. 27
Issue 9
Pg. 658-64
(Sep 2006)
ISSN: 0248-8663 [Print] France |
Vernacular Title | Profils évolutifs et marqueurs pronostiques de la maladie de Still de l'adulte. Analyse d'une série monocentrique de 17 patients. |
PMID | 16750873
(Publication Type: Comparative Study, English Abstract, Journal Article)
|
Chemical References |
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Aspirin
- Methotrexate
|
Topics |
- Adolescent
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Adult
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, therapeutic use)
- Antirheumatic Agents
(administration & dosage, therapeutic use)
- Aspirin
(administration & dosage, therapeutic use)
- Cohort Studies
- Data Interpretation, Statistical
- Female
- Follow-Up Studies
- Humans
- Male
- Methotrexate
(administration & dosage, therapeutic use)
- Middle Aged
- Prognosis
- Prospective Studies
- Retrospective Studies
- Still's Disease, Adult-Onset
(diagnosis, drug therapy)
- Time Factors
- Treatment Outcome
|