Malignant islet cell tumor of the pancreas with multiple hormone production and expression of CEA and CA19-9. Report of an autopsy case.

Abstract

An autopsy case of malignant islet cell tumor of the pancreas is presented. The patient, a 64-year-old woman showed severe hypoglycemia as the initial symptom, and hyperinsulinemia was demonstrated by laboratory examinations. Metastatic tumors in the liver were found by abdominal computed tomography. Autopsy revealed a tumor measuring 6.5 x 3 x 2 cm occupying the pancreas from the body to the tail. From the results of histological and immunohistochemical studies, this was diagnosed as a malignant islet cell tumor producing multiple hormones such as insulin, glucagon, somatostatin and pancreatic polypeptide, as well as expressing the tumor-related antigens CEA and CA19-9. These findings suggested that the tumor cells showed differentiation to both endocrine cells and pancreatic duct cells.

• Authors: K Arihiro, K Inai
• Journal: Acta pathologica japonica (Acta Pathol Jpn) Vol. 41 Issue 2 Pg. 150-7 (Feb 1991) ISSN: 0001-6632 [Print] Australia
• PMID: 1675032 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Carcinoembryonic Antigen
• Insulin
• Somatostatin
• Pancreatic Polypeptide
• Glucagon

Topics

• Adenoma, Islet Cell (metabolism, pathology)
• Antigens, Tumor-Associated, Carbohydrate (metabolism)
• Autopsy
• Carcinoembryonic Antigen (metabolism)
• Female
• Glucagon (metabolism)
• Humans
• Immunohistochemistry
• Insulin (metabolism)
• Middle Aged
• Pancreatic Neoplasms (metabolism, pathology)
• Pancreatic Polypeptide (metabolism)
• Somatostatin (metabolism)