Inhaled fluticasone propionate and adrenal effects in adult asthma: systematic review and meta-analysis.

Abstract	The dose-response relationship of inhaled fluticasone propionate (FP) for adrenal suppression in adults with asthma is not clear. The current authors carried out a systematic review and meta-analysis of placebo-controlled randomised dose-response studies of >or=4 weeks' duration, which assessed the adrenal effects of FP by cosyntropin stimulation tests in adult asthma. The main outcome measure was the proportion of subjects with adrenal function below the lower limit of the normal range. Five studies, with a total of 732 subjects with asthma, met the inclusion criteria. Data on daily doses >1,000 mug were limited to one study. The proportion of subjects with adrenal function below the lower limit of the normal range on placebo was 3.9%; for a 500-microg per day increase in FP dose the odds of an abnormality increased by 1.38 (95% confidence interval 1.01-1.59). The continuous secondary outcome measures showed an inverse linear relationship with the FP dose up to 2,000 microg.day(-1). In conclusion, for routine prescribing within the established therapeutic dose-response range (50-500 microg.day(-1)), fluticasone propionate has minimal effects on adrenal function. This conclusion is limited by the paucity of long-term studies of daily doses of fluticasone propionate >1,000 mug and by the considerable individual variability in the response.
Authors	M Masoli, M Weatherall, S Holt, P Shirtcliffe, R Beasley
Journal	The European respiratory journal (Eur Respir J) Vol. 28 Issue 5 Pg. 960-7 (Nov 2006) ISSN: 0903-1936 [Print] England
PMID	16737984 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
Chemical References	Androstadienes Bronchodilator Agents Fluticasone
Topics	Adrenal Insufficiency (chemically induced) Adult Androstadienes (administration & dosage, adverse effects) Asthma (complications, drug therapy) Bronchodilator Agents (administration & dosage, adverse effects) Dose-Response Relationship, Drug Fluticasone Humans Randomized Controlled Trials as Topic

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