[Acute-phase reactants and markers of inflammation in venous thromboembolic disease: correlation with clinical and evolution parameters].

Abstract

OBJECTIVE:

To asses the association of acute reactants and interleukin 6 and 8 (IL-6 & IL-8) at diagnosis of venous thromboembolic disease (VTD) and clinical outcome.

METHODS:

100 patients were diagnosed of VTD by image tests. Acute reactants (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen), D-dimer and IL-6 and IL-8 we measured at the moment of diagnosis. We made a 12 month follow-up of these patients to notice any clinical evolution outcomes (recurrences, bleeding, post-phlebitic syndrome, death).

RESULTS:

IL-6 was increased in 9 patients and IL-8 in 3. The risk factors, time to diagnosis and pulmonary embolism rate were similar in both interleukin groups (normal and high levels). Fibrinogen levels were significantly increased in high IL-6 group (585 +/- 179 vs. 485 +/- 154 mgr/dl; p = 0.05). During follow-up there were 5 deaths, 3 recurrences, 11 bleedings and 43 postphlebitic syndromes. Normal ESR level was associated to postphlebitic syndrome (17.8 +/- 14.5 vs. 31.4 +/- 27.4 mm/1st h; p = 0.016). Patients who had high levels of IL-6 had worse survival than these with normal levels (p = 0.015).

CONCLUSION:

IL-6, ESR, and CPR at diagnosis of VTD could be useful to identified patients with higher risks of death and postphlebitic syndrome during the first year after diagnosis.

• Authors: P J Marchena Yglesias, J A Nieto Rodríguez, S Serrano Martínez, O Belinchón Moya, A Cortés Carmona, A Díaz de Tuesta, M J Bruscas Alijarde, M D Ruiz Ribó
• Journal: Anales de medicina interna (Madrid, Spain : 1984) (An Med Interna) Vol. 23 Issue 3 Pg. 105-10 (Mar 2006) ISSN: 0212-7199 [Print] Spain
• Vernacular Title: Reactantes de fase aguda y marcadores de inflamación en pacientes con enfermedad tromboembólica venosa: correlación con parámetros clínicos y evolutivos.
• PMID: 16737429 (Publication Type: English Abstract, Journal Article)

Chemical References

• Acute-Phase Proteins
• Biomarkers
• Fibrin Fibrinogen Degradation Products
• Interleukin-6
• Interleukin-8
• fibrin fragment D
• Fibrinogen
• C-Reactive Protein

Topics

• Acute-Phase Proteins (analysis)
• Adult
• Aged
• Aged, 80 and over
• Biomarkers
• Blood Sedimentation
• C-Reactive Protein (analysis)
• Comorbidity
• Female
• Fibrin Fibrinogen Degradation Products (analysis)
• Fibrinogen (analysis)
• Follow-Up Studies
• Humans
• Inflammation (blood)
• Interleukin-6 (blood)
• Interleukin-8 (blood)
• Male
• Middle Aged
• Postoperative Complications (blood, diagnosis, mortality)
• Postphlebitic Syndrome (blood, epidemiology)
• Predictive Value of Tests
• Prognosis
• Prospective Studies
• Pulmonary Embolism (blood, diagnosis, mortality)
• Risk Factors
• Thrombophlebitis (blood, diagnosis, mortality)
• Treatment Outcome