High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer.

Abstract

The present study investigated the mRNA expression level of ubiquitin c-terminal hydrolase (UCH)-L1 and -L3 in breast cancer tissue and aimed to elucidate its association with tumor characteristics and patient prognosis. UCH-L1 and UCH-L3 mRNA levels in invasive breast cancer (n = 100) were determined by a real-time polymerase chain reaction (PCR) assay and their relationship with various clinicopathological characteristics of breast tumors as well as patient prognosis were studied. UCH-L3 mRNA level was significantly upregulated in breast cancer tissue compared to adjacent normal breast tissue (P < 0.005), and UHC-L1 mRNA level also showed a non-significant increase in tumor tissue compared to adjacent normal breast tissue. Both UCH-L1 and UCH-L3 mRNA levels were significantly higher in high histological grade tumors than in low histological grade tumors (P < 0.001 and P < 0.005, respectively). High UCH-L1 mRNA level was significantly associated with negative estrogen receptor status (P < 0.05) and negative progesterone receptor status (P < 0.05). Patients with both UCH-L1 and UCH-L3 mRNA high tumors showed a significantly poorer prognosis than those in the UCH-L1 or UCH-L3 mRNA low group (P < 0.005). These observations that UCH-L3 mRNA level is upregulated in breast cancer tissue, and breast tumors with both UCH-L1 and UCH-L3 mRNA high expression are associated with a poor prognosis, suggest the possible involvement of UCH-L1 and UCH-L3 in the pathogenesis and progression of breast cancer.

• Authors: Yasuo Miyoshi, Satoshi Nakayama, Yasuhiro Torikoshi, Satoshi Tanaka, Hideki Ishihara, Tetsuya Taguchi, Yasuhiro Tamaki, Shinzaburo Noguchi
• Journal: Cancer science (Cancer Sci) Vol. 97 Issue 6 Pg. 523-9 (Jun 2006) ISSN: 1347-9032 [Print] England
• PMID: 16734731 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD
• Biomarkers, Tumor
• RNA, Messenger
• Receptors, Estrogen
• Receptors, Progesterone
• Ubiquitin Thiolesterase

Topics

• Antigens, CD (metabolism)
• Biomarkers, Tumor (analysis)
• Breast Neoplasms (enzymology, pathology)
• Female
• Humans
• Neoplasm Recurrence, Local (metabolism, pathology)
• Postmenopause
• Premenopause
• Prognosis
• RNA, Messenger (analysis)
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)
• Reverse Transcriptase Polymerase Chain Reaction
• Ubiquitin Thiolesterase (biosynthesis)