[Effect of polymorphism of human intestinal fatty acid binding protein gene on the therapeutic efficacy of fenofibrate].

Abstract

OBJECTIVE:

To explore the effect of polymorphism in codon Ala54Thr of human intestinal fatty acid-binding protein gene (IFABP) on the therapeutic efficacy of fenofibrate.

METHODS:

Totally 147 patients with hyperlipidemia [72 men mean age: (56.2 +/- 8.63) years; 75 women mean age: (58.4 +/- 9.12) years] were enrolled. IFABP genotypes were detected by polymerase chain reaction, Hha I digestion, and sequencing. Four weeks before and after treatment, the levels of fasting serum total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), apolipoprotein A I (apoA I) and apolipoprotein B (apoB) were detected with biochemical techniques.

RESULTS:

The frequency of IFABP genotype was 0.47 for A/A, 0.37 for A/T, and 0.16 for T/T, and the allelic frequency was 0.65 for A and 0.35 for T. No significant different was found in lipid levels in every genotype before treatment (P > 0.05). After 4 weeks of treatment, the levels of TC, TG, LDL-C, and apoB significantly decreased (P < 00.01), and the levels of HDH-C and apoA I significantly increased (P < 0.01). The total therapeutic efficacy on A54A and A54T were 97% and 95%, respectively. In the patients with T54T genotype after treatment, no significant difference in lipids levels was found except TG (P < 0.05), and the total efficacy was only 38%. The total therapeutic efficacies of fenofibrate on A54A and A54T were higher than those of T54T, and there was significant different between A54A and T54T (P < 0.01).

CONCLUSION:

The polymorphism of human IFABP gene in hyperlipidemia is related with the therapeutic efficacy of fenofibrate, and the T54T IFABP genotype may have strong negative effect on such efficacy.

• Authors: Xiao-tong Chang, Zhen-hui Wang, Xin Du, Ming-gang Dong, Li-juan Hou, Jie Liu, Jian Wang, Jian-guang Zhou
• Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 28 Issue 2 Pg. 230-3 (Apr 2006) ISSN: 1000-503X [Print] China
• PMID: 16733910 (Publication Type: English Abstract, Journal Article)

Chemical References

• Apolipoproteins
• Fatty Acid-Binding Proteins
• Hypolipidemic Agents
• Lipids
• Fenofibrate

Topics

• Aged
• Apolipoproteins (blood)
• Fatty Acid-Binding Proteins (genetics)
• Female
• Fenofibrate (therapeutic use)
• Gene Frequency
• Genotype
• Humans
• Hyperlipidemias (blood, drug therapy, genetics)
• Hypolipidemic Agents (therapeutic use)
• Lipids (blood)
• Male
• Middle Aged
• Polymorphism, Genetic
• Treatment Outcome