Abstract |
Polyomavirus (PV) infection is associated with ureteral stenosis, hemorrhagic cystitis, and interstitial nephritis in renal transplant patients. The 3 PVs detected in human beings-BK virus, JC virus, and simian virus 40-each encode highly homologous forms of a large T antigen, a transcriptional and replicational regulatory protein. We describe immunohistochemical findings in 5 renal transplant patients who developed PV nephropathy (PVN) and a sixth patient with both PVN and PV infection of the bladder mucosa. Polyomavirus infection was confirmed by immunohistochemical detection of T antigen in kidney and bladder biopsies. We report on the expression of p53 specific to virally infected cells in all biopsies positive for T antigen. Examination of posttransplant biopsies obtained from these 6 patients before they were diagnosed with PVN revealed no expression of T antigen or p53. Accumulation of p53 in PV-infected cells may occur in response to binding of p53 by T antigen, resulting in stabilization of p53. These results provide the first evidence for intracellular actions of PV T antigen in the context of nonneoplastic diseases.
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Authors | David B Weinreb, Garrett T Desman, David E Burstein, Dae Un Kim, Steven H Dikman, Edward M Johnson |
Journal | Human pathology
(Hum Pathol)
Vol. 37
Issue 6
Pg. 684-8
(Jun 2006)
ISSN: 0046-8177 [Print] United States |
PMID | 16733208
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Viral, Tumor
- Tumor Suppressor Protein p53
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Topics |
- Antigens, Viral, Tumor
(immunology)
- Biopsy
- Humans
- Kidney Transplantation
- Kidney Tubules
(pathology, virology)
- Polyomavirus
(immunology, isolation & purification, pathogenicity)
- Polyomavirus Infections
(pathology)
- Transplantation, Homologous
- Tumor Suppressor Protein p53
(genetics, metabolism)
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