Successful treatment for obsessive-compulsive disorder with addition of low-dose risperidone to fluvoxamine: implications for plasma levels of catecholamine metabolites and serum brain-derived neurotrophic factor levels.

Abstract	The authors report on the successful treatment of obsessive-compulsive disorder (OCD) in three patients with the addition of risperidone to ongoing fluvoxamine treatment. Plasma homovanillic acid (HVA), but not 3-methoxy-4-hydroxyphenylglycol (MHPG) levels decreased after risperidone administration, and plasma levels of fluvoxamine did not change. In addition, serum brain-derived neurotrophic factor (BDNF) levels were not altered after the recovery from obsessive-compulsive symptoms, indicating that serum BDNF levels might not predict the patient's response to risperidone treatment. Taken together, a combination treatment of risperdone and fluvoxamine might improve obsessive-compulsive symptoms. In short, fluvoxamine enhances the activity of the serotonergic system by inhibiting serotonin transporters, and risperidone decreases that of the dopaminergic system by blocking D2 receptors.
Authors	Reiji Yoshimura, Sachiko Kaneko, Koji Shinkai, Jun Nakamura
Journal	Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 60 Issue 3 Pg. 389-93 (Jun 2006) ISSN: 1323-1316 [Print] Australia
PMID	16732759 (Publication Type: Case Reports, Journal Article)
Chemical References	Antipsychotic Agents Brain-Derived Neurotrophic Factor Catecholamines Serotonin Antagonists Serotonin Uptake Inhibitors Methoxyhydroxyphenylglycol Risperidone Fluvoxamine Homovanillic Acid
Topics	Adult Antipsychotic Agents (blood, therapeutic use) Brain-Derived Neurotrophic Factor (blood) Catecholamines (metabolism) Dose-Response Relationship, Drug Drug Therapy, Combination Female Fluvoxamine (blood, therapeutic use) Homovanillic Acid (blood) Humans Male Methoxyhydroxyphenylglycol (blood) Obsessive-Compulsive Disorder (drug therapy) Risperidone (blood, therapeutic use) Serotonin Antagonists (blood, therapeutic use) Selective Serotonin Reuptake Inhibitors (blood, therapeutic use)

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