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The role of CD4 T cells in the pathogenesis of murine AIDS.

Abstract
LP-BM5, a retroviral isolate, induces a disease featuring retrovirus-induced immunodeficiency, designated murine AIDS (MAIDS). Many of the features of the LP-BM5-induced syndrome are shared with human immunodeficiency virus-induced disease. For example, CD4 T cells are critical to the development of MAIDS. In vivo depletion of CD4 T cells before LP-BM5 infection rendered genetically susceptible B6 mice MAIDS resistant. Similarly, MAIDS did not develop in B6.nude mice. However, if reconstituted with CD4 T cells, B6.nude mice develop full-blown MAIDS. Our laboratory has shown that the interaction of B and CD4 T cells that is central to MAIDS pathogenesis requires ligation of CD154 on CD4 T cells with CD40 on B cells. However, it is not clear which additional characteristics of the phenotypically and functionally heterogeneous CD4 T-cell compartment are required. Here, in vivo adoptive transfer experiments using B6.nude recipients are employed to compare the pathogenic abilities of CD4 T-cell subsets defined on the basis of cell surface phenotypic or functional differences. Th1 and Th2 CD4 T cells equally supported MAIDS induction. The rare Thy1.2(-) CD4 subset that expands upon LP-BM5 infection was not necessary for MAIDS. Interestingly, CD45RB(low) CD4 T cells supported significantly less disease than CD45RB(high) CD4 T cells. Because the decreased MAIDS pathogenesis could not be attributed to inhibition by CD45RB(low) CD25(+) natural T-regulatory cells, an intrinsic property of the CD45RB(low) cells appeared responsible. Similarly, there was no evidence that natural T-regulatory cells played a role in LP-BM5-induced pathogenesis in the context of the intact CD4 T-cell population.
AuthorsWen Li, William R Green
JournalJournal of virology (J Virol) Vol. 80 Issue 12 Pg. 5777-89 (Jun 2006) ISSN: 0022-538X [Print] United States
PMID16731917 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Leukocyte Common Antigens
Topics
  • Adoptive Transfer
  • Animals
  • CD4-Positive T-Lymphocytes (physiology, virology)
  • Leukocyte Common Antigens
  • Mice
  • Mice, Inbred Strains
  • Mice, Nude
  • Murine Acquired Immunodeficiency Syndrome (etiology)
  • Retroviridae (pathogenicity)
  • Species Specificity
  • T-Lymphocytes, Regulatory (virology)
  • Th1 Cells (virology)
  • Th2 Cells (virology)

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