Abstract | BACKGROUND: OBJECTIVE: METHODS: We compared patients who met modified New York criteria for AS to healthy untreated controls. Serum tissue factor was assayed using an ELISA. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Bath Ankylosing Spondylitis Global Score (BAS-G) were recorded, as well as the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and IgA level. ANOVA and t-tests were performed. P values<0.05 were considered significant. RESULTS: We included 28 patients with AS (mean age, 42 years; and mean disease duration, 14 years), who had never received immunomodulating or vascular medications, and 22 same-age healthy controls. In the patients, tissue factor levels were significantly higher (32.6+/-33.6 vs. 9.5+/-11.5 pg/ml, P=0.003); they correlated with the ESR (P=0.018), CRP (P<0.0001), and IgA (P=0.023), but not with the clinical variables (BASDAI, BASFI, and BAS-G; P>0.05). CONCLUSION: In this preliminary study in patients with AS, tissue factor levels were high and correlated with laboratory tests for inflammation. Tissue factor elevation may be a cause or a consequence of AS inflammation that promotes the occurrence of vascular events.
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Authors | Daniel Wendling, Evelyne Racadot |
Journal | Joint bone spine
(Joint Bone Spine)
Vol. 73
Issue 4
Pg. 403-5
(Jul 2006)
ISSN: 1297-319X [Print] France |
PMID | 16730212
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- C-Reactive Protein
- Thromboplastin
|
Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Blood Sedimentation
- C-Reactive Protein
(metabolism)
- Disease Progression
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Male
- Middle Aged
- Severity of Illness Index
- Spondylitis, Ankylosing
(blood, pathology)
- Thromboplastin
(metabolism)
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