Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas.

Abstract	Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated-estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.
Authors	Salama A Salama, Shu-Leong Ho, Hui-Qun Wang, Jukka Tenhunen, Carola Tilgmann, Ayman Al-Hendy
Journal	Fertility and sterility (Fertil Steril) Vol. 86 Issue 1 Pg. 259-62 (Jul 2006) ISSN: 1556-5653 [Electronic] United States
PMID	16730007 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	Gonadal Steroid Hormones Estradiol Dexamethasone
Topics	Animals Dexamethasone (administration & dosage) Dose-Response Relationship, Drug Enzyme Activation (drug effects) Estradiol (administration & dosage) Female Gonadal Steroid Hormones (administration & dosage) Humans Leiomyoma (enzymology) Rats Tumor Cells, Cultured Uterine Neoplasms (enzymology)

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