Abstract |
We report five children with atopic eczema. The level of soluble adhesion molecules is known to correlate with disease severity. On the assumption that atopic eczema is a T-lymphocyte-mediated inflammatory disease, in this study, we aimed to determine the presence of soluble intracellular adhesion molecule (sICAM) 1 and the release of inflammatory cytokines. The patient sera were used to measure sICAM-1 by enzyme-linked immunosorbent assay, and the concentration of interleukin (IL)-4 and IL-5 in whole blood culture supernatant was determined by a flow cytometry microsphere-based assay. sICAM-1 was dramatically higher in these patients than healthy controls. In addition, the results showed an increase in IL-4 and IL-5 concentration compared with control subjects. In conclusion, these results showed that sICAM-1 expression is important in inflammation of epithelial cells and can be used as a useful parameter in monitoring the disease activity. The study suggests that T-helper cell subset plays an important role in initiating eczematous disease and that additional studies are needed to explore such a role.
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Authors | Faris Q B Alenzi |
Journal | Allergy and asthma proceedings
(Allergy Asthma Proc)
2006 Mar-Apr
Vol. 27
Issue 2
Pg. 126-9
ISSN: 1088-5412 [Print] United States |
PMID | 16724631
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-5
- Intercellular Adhesion Molecule-1
- Interleukin-4
- Immunoglobulin E
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Topics |
- Case-Control Studies
- Child
- Child, Preschool
- Eczema
(blood, pathology)
- Humans
- Immunoglobulin E
(blood)
- Intercellular Adhesion Molecule-1
(blood)
- Interleukin-4
(blood)
- Interleukin-5
(blood)
- Leukocyte Count
- Saudi Arabia
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