Abstract |
The effects of dextromethorphan (DM, CAS 6700-34-1), a common over-the-counter cough suppressant, on the reference memory have been investigated by a three-panel runway setup in rats. This study was designed by using a repeated acquisition procedure such as a radialarm maze task or a water maze task. DM (20-40 mg/kg i.p.) produced a significant decrease in the number of errors (pushes made on the two incorrect panels of the three panel gates at four choice points) and latency. Systemically administered scopolamine (CAS 114-49-8) (1 mg/kg i.p.) impaired the performance on both parameters. DM (40 mg/kg i.p.) was effective in reversing the reference memory deficit induced by administration of scopolamine. DM acts as a noncompetitive antagonist of the N-methyl-D-aspartate ( NMDA) receptors. Our results suggest that inhibition of NMDA receptors by DM supports its potential positive properties. This finding might present an oppurtunity for the evaluation of this old antitussive drug.
|
Authors | Semil Selcen Göçmez, Bekir Faruk Erden, Güner Ulak, Tijen Utkan, Füruzan Yildiz, Nejat Gacar, Oguz Mutlu |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 56
Issue 4
Pg. 276-81
( 2006)
ISSN: 0004-4172 [Print] Germany |
PMID | 16724513
(Publication Type: Journal Article)
|
Chemical References |
- Antitussive Agents
- Muscarinic Antagonists
- Receptors, N-Methyl-D-Aspartate
- Dextromethorphan
- Scopolamine
|
Topics |
- Animals
- Antitussive Agents
(pharmacology)
- Conditioning, Operant
(drug effects)
- Dextromethorphan
(pharmacology)
- Learning
(drug effects)
- Male
- Maze Learning
(drug effects)
- Memory
(drug effects)
- Muscarinic Antagonists
(pharmacology)
- Psychomotor Performance
(drug effects)
- Rats
- Rats, Wistar
- Receptors, N-Methyl-D-Aspartate
(drug effects)
- Scopolamine
(pharmacology)
|