Efficacy of voriconazole in a guinea pig model of invasive trichosporonosis.

Abstract

We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Trichosporon asahii in immunosuppressed guinea pigs. VRC was more effective than amphotericin B in prolonging survival and reducing tissue burden. The best results were obtained with VRC at 10 mg/kg of body weight/day.

• Authors: Carolina Serena, Félix Gilgado, Marçal Mariné, F Javier Pastor, Josep Guarro
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 50 Issue 6 Pg. 2240-3 (Jun 2006) ISSN: 0066-4804 [Print] United States
• PMID: 16723595 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Pyrimidines
• Triazoles
• Amphotericin B
• Voriconazole

Topics

• Amphotericin B (therapeutic use)
• Animals
• Antifungal Agents (therapeutic use)
• Colony Count, Microbial (statistics & numerical data)
• Disease Models, Animal
• Guinea Pigs
• Humans
• Kidney (microbiology)
• Liver (microbiology)
• Microbial Sensitivity Tests
• Mycoses (drug therapy, mortality)
• Pyrimidines (therapeutic use)
• Spleen (microbiology)
• Survival Analysis
• Triazoles (therapeutic use)
• Trichosporon (drug effects, genetics, isolation & purification)
• Voriconazole