HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Aerobic conditioning: an effective therapy in McArdle's disease.

AbstractOBJECTIVE:
Susceptibility to exertional cramps and rhabdomyolysis in myophosphorylase deficiency (McArdle's disease [MD]) may lead patients to shun exercise. However, physical inactivity may worsen exercise intolerance by further reducing the limited oxidative capacity caused by blocked glycogenolysis. We investigated whether aerobic conditioning can safely improve exercise capacity in MD.
METHODS:
Eight MD patients (4 men and 4 women; age range, 33-61 years) pedalled a cycle ergometer for 30 to 40 minutes a day, 4 days a week, for 14 weeks, at an intensity corresponding to 60 to 70% of maximal heart rate. We monitored serum creatine kinase levels; changes in peak cycle work, oxygen uptake, and cardiac output; presence and magnitude of a spontaneous and glucose-induced second wind; and citrate synthase and beta-hydroxyacyl coenzyme A dehydrogenase enzyme activities in quadriceps muscle.
RESULTS:
The prescribed exercise program increased average work capacity (36%), oxygen uptake (14%), cardiac output (15%), and citrate synthase and beta-hydroxyacyl coenzyme A dehydrogenase enzyme levels (80 and 62%, respectively) without causing pain or cramping or increasing serum creatine kinase. A spontaneous and glucose-induced second wind was present and was of similar magnitude in each patient before and after training.
INTERPRETATION:
Moderate aerobic exercise is an effective means of improving exercise capacity in MD by increasing circulatory delivery and mitochondrial metabolism of bloodborne fuels.
AuthorsRonald G Haller, Phil Wyrick, Tanja Taivassalo, John Vissing
JournalAnnals of neurology (Ann Neurol) Vol. 59 Issue 6 Pg. 922-8 (Jun 2006) ISSN: 0364-5134 [Print] United States
PMID16718692 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightAnn Neurol 2006;59:922-928.
Chemical References
  • 3-Hydroxyacyl CoA Dehydrogenases
  • Citrate (si)-Synthase
  • Creatine Kinase
  • Glucose
Topics
  • 3-Hydroxyacyl CoA Dehydrogenases (metabolism)
  • Adult
  • Cardiac Output (physiology)
  • Citrate (si)-Synthase (metabolism)
  • Creatine Kinase (blood)
  • Exercise Therapy
  • Female
  • Glucose (metabolism)
  • Glycogen Storage Disease Type V (therapy)
  • Humans
  • Male
  • Middle Aged
  • Oxygen Consumption (physiology)
  • Physical Fitness (physiology)
  • Quadriceps Muscle (enzymology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: