Reinke's oedema, hormones and hormone replacement therapy.

Abstract

OBJECTIVE:

To study the implications of hormone replacement therapy (HRT) treatment in the pathogenesis of Reinke's oedema (via a possible pseudo-hypothyroidism effect), and also to study why the disease affects a predominantly post-menopausal female population.

DESIGN:

Prospective case series study.

SETTING:

Two teaching hospitals and two district general hospitals in Scotland, UK.

SUBJECTS:

Thirty-three patients diagnosed with Reinke's oedema who presented in the out-patient department before or after treatment.

RESULTS:

Thyroid function tests were normal in all but two cases. Only three patients were receiving HRT treatment.

CONCLUSIONS:

The study produced no evidence to support a relationship between HRT treatment and the pathogenesis of Reinke's oedema; this supports previous studies which concluded that thyroid function was not related to the development of Reinke's oedema. Some new ideas regarding hormonal factors in Reinke's oedema are discussed.

• Authors: A Tsikoudas, X Kochillas, G Vernham
• Journal: The Journal of laryngology and otology (J Laryngol Otol) Vol. 120 Issue 10 Pg. 849-52 (Oct 2006) ISSN: 1748-5460 [Electronic] England
• PMID: 16716238 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Thyroid Hormones

Topics

• Adult
• Aged
• Female
• Hormone Replacement Therapy (adverse effects)
• Humans
• Hypothyroidism (complications)
• Laryngeal Edema (etiology)
• Middle Aged
• Postmenopause
• Prospective Studies
• Scotland
• Smoking (adverse effects)
• Thyroid Function Tests
• Thyroid Hormones (metabolism)