Abstract | OBJECTIVE: SUBJECTS AND METHODS: In vitro antituberculous activity of OFLX and LVFX against multidrug-resistant strains of Mycobacterium tuberculosis isolated from 46 patients with pulmonary tuberculosis and a retropective clinical analysis of 45 patients were investigated. RESULTS: In susceptibility testing, resistance rates to OFLX or LVFX were higher in intractable cases (7/20: 35%) and in cases with prior chemotherapy using new quinolones (5/12: 42 %). Sputum culture conversion was observed in 34 patients (76%), however 9 among them later reverted to positive culture. In a single variate proportional hazards model, risk factors related to poor outcomes (treatment failure or relapse) were resistance to OFLX or LVFX, advanced disease on chest radiograph, and the number of susceptible drugs four or less. In a multiple variate proportional hazards model, a risk factor was resistance to OFLX or LVFX. Eighteen patients (40%) died, and among them, 10 died of tuberculosis. Survival time of treatment failure patients was significantly shorter than patients with sputum culture conversion. CONCLUSION:
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Authors | Atsuhiko Tada, Noriko Kawata, Takuo Shibayama, Shuji Takahashi, Atsushi Hirano, Goro Kimura, Makoto Takeuchi, Chiharu Okada, Ryo Soda, Kiyoshi Takahashi |
Journal | Kekkaku : [Tuberculosis]
(Kekkaku)
Vol. 81
Issue 4
Pg. 337-44
(Apr 2006)
ISSN: 0022-9776 [Print] Japan |
PMID | 16715942
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Levofloxacin
- Ofloxacin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anti-Infective Agents
(pharmacology, therapeutic use)
- Drug Resistance, Multiple, Bacterial
- Female
- Humans
- Levofloxacin
- Male
- Middle Aged
- Mycobacterium tuberculosis
(drug effects)
- Ofloxacin
(pharmacology, therapeutic use)
- Treatment Outcome
- Tuberculosis, Multidrug-Resistant
(drug therapy)
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