Abstract | PURPOSE: To describe the spectrum and treatment of orbital Rosai-Dorfman disease and to review previously documented cases. METHODS: Retrospective, interventional case series of seven patients and literature review. RESULTS: Each patient with Rosai-Dorfman disease had unique disease expression requiring aggressive therapy, such as chemotherapy, radiation, and/or surgical excision. One systemically aggressive case presented with intraocular and choroidal invasion, a previously unreported finding. Response to therapy was variable and unpredictable. CONCLUSIONS:
Rosai-Dorfman disease, although historically described as benign and self-limiting, may cause significant morbidity and mortality involving multiple organ systems. Available treatment options may not control the disease. Further research and long-term clinical correlation is necessary.
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Authors | Yasaman Mohadjer, John B Holds, Jack Rootman, Mathew W Wilson, James W Gigantelli, Philip L Custer |
Journal | Ophthalmic plastic and reconstructive surgery
(Ophthalmic Plast Reconstr Surg)
2006 May-Jun
Vol. 22
Issue 3
Pg. 163-8
ISSN: 0740-9303 [Print] United States |
PMID | 16714922
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Adult
- Female
- Histiocytosis, Sinus
(complications, diagnosis, drug therapy)
- Humans
- Male
- Middle Aged
- Orbital Diseases
(complications, diagnosis, drug therapy)
- Retrospective Studies
- Tomography, X-Ray Computed
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