Abstract |
In the cat only 10 cases of mesothelioma, mainly of the peritoneum, have been previously reported. This paper describes a further 10 cases, eight pleural and two peritoneal, in males and females aged 1-17 years. Histologically, five tumours were epithelial, three fibrosarcomatous and two biphasic. Immunohistochemical markers used in human pathology for the identification of mesotheliomas include vimentin, cytokeratin (CK) AE1/AE3, HBME-1, CK 5/6, calretinin, thrombomodulin, carcinoembryonic antigen (CEA), CD15, E-cadherin and desmin. All 10 feline mesotheliomas were positive for vimentin and CK AE1/AE3, six were positive for HBME-1, two for CK5/6, three for CEA and four for E-cadherin. All were negative for desmin and calretinin. Antibodies to thrombomodulin and CD15 failed to cross-react with feline tissues. Electron microscopy, performed in four cases, revealed microvillar structures, desmosomes and intracytoplasmic lumina, confirming its value as a diagnostic tool. The study showed that mesothelial marker antibodies commonly used in human patients can be used for the diagnosis of feline mesothelioma, preferably as a panel of antibodies rather than only one.
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Authors | B Bacci, F Morandi, M De Meo, P S Marcato |
Journal | Journal of comparative pathology
(J Comp Pathol)
Vol. 134
Issue 4
Pg. 347-54
(May 2006)
ISSN: 0021-9975 [Print] England |
PMID | 16712862
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Animals
- Biomarkers, Tumor
(analysis)
- Cat Diseases
(pathology)
- Cats
- Cytoplasmic Structures
(ultrastructure)
- Desmosomes
(ultrastructure)
- Female
- Immunoenzyme Techniques
(veterinary)
- Male
- Mesothelioma
(chemistry, pathology, veterinary)
- Microscopy, Electron, Transmission
(veterinary)
- Microvilli
(ultrastructure)
- Peritoneal Neoplasms
(chemistry, pathology, veterinary)
- Pleura
(ultrastructure)
- Pleural Neoplasms
(chemistry, pathology, veterinary)
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