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[Efficacy of rituximab in hairy cell leukemia].

AbstractINTRODUCTION:
Rituximab is an alternative treatment for hairy cell leukemia, when the standard treatments are unavailable.
CASE:
An 82-year-old woman was diagnosed with hairy cell leukemia. The severity of her neutropenia ruled out purine analogs, while heart disease and age both contraindicated use of interferon. Rituximab, in four weekly treatments, was effective from the first treatment and the positive response was sustained thereafter.
DISCUSSION:
Rituximab may be used to treat hairy cell leukemia, especially for patients refractory to purine analogs or after relapse or in the case of severe neutropenia, when interferon is contraindicated.
AuthorsJean-Valère Malfuson, Kamal Doghmi, Thierry Fagot, Bertrand Souleau, Thierry De Revel, Gérard Nedellec
JournalPresse medicale (Paris, France : 1983) (Presse Med) Vol. 35 Issue 5 Pt 1 Pg. 801-2 (May 2006) ISSN: 0755-4982 [Print] France
Vernacular TitleEfficacité du rituximab dans la leucémie à tricholeucocytes.
PMID16710151 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Agents
  • Rituximab
Topics
  • Aged, 80 and over
  • Antibodies, Monoclonal (therapeutic use)
  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Agents (therapeutic use)
  • Female
  • Humans
  • Leukemia, Hairy Cell (drug therapy, immunology)
  • Neutropenia (complications)
  • Rituximab

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