Abstract | BACKGROUND: APPROACH: We reviewed recent studies focusing on the pathophysiologic functions and clinical significance of Gc-globulin. RESULTS: Serum concentrations of Gc-globulin, as determined by immunoassay techniques, are decreased in severe injury. The extent of the decrease may have prognostic significance for patient outcomes. Clinical studies and animal models have shown that Gc-globulin has an important role in the clearance of procoagulant actin from the circulation after its release during cell necrosis and tissue injury. Gc-globulin has other potential roles in responses to acute tissue injury through conversion to a macrophage-activating factor, neutrophil chemotactic activity, and enhancement of C5a-mediated signaling. CONCLUSION: Considering the important physiologic roles of Gc-globulin in responses to tissue injury, such as clearance of actin, measurement of Gc-globulin may have value in directing the care of patients in many clinical disorders.
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Authors | Ursula Meier, Olav Gressner, Frank Lammert, Axel M Gressner |
Journal | Clinical chemistry
(Clin Chem)
Vol. 52
Issue 7
Pg. 1247-53
(Jul 2006)
ISSN: 0009-9147 [Print] England |
PMID | 16709624
(Publication Type: Journal Article, Review)
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Chemical References |
- Actins
- Biomarkers
- Vitamin D-Binding Protein
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Topics |
- Actins
(physiology)
- Acute Kidney Injury
(metabolism, physiopathology)
- Biomarkers
(analysis)
- Humans
- Immunoassay
- Sepsis
(metabolism, physiopathology)
- Vitamin D-Binding Protein
(analysis, genetics, physiology)
- Wounds and Injuries
(metabolism, physiopathology)
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