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Gc-globulin: roles in response to injury.

AbstractBACKGROUND:
Gc-globulin (vitamin D-binding protein) appears to have important functions in addition to its role as a carrier of vitamin D.
APPROACH:
We reviewed recent studies focusing on the pathophysiologic functions and clinical significance of Gc-globulin.
RESULTS:
Serum concentrations of Gc-globulin, as determined by immunoassay techniques, are decreased in severe injury. The extent of the decrease may have prognostic significance for patient outcomes. Clinical studies and animal models have shown that Gc-globulin has an important role in the clearance of procoagulant actin from the circulation after its release during cell necrosis and tissue injury. Gc-globulin has other potential roles in responses to acute tissue injury through conversion to a macrophage-activating factor, neutrophil chemotactic activity, and enhancement of C5a-mediated signaling.
CONCLUSION:
Considering the important physiologic roles of Gc-globulin in responses to tissue injury, such as clearance of actin, measurement of Gc-globulin may have value in directing the care of patients in many clinical disorders.
AuthorsUrsula Meier, Olav Gressner, Frank Lammert, Axel M Gressner
JournalClinical chemistry (Clin Chem) Vol. 52 Issue 7 Pg. 1247-53 (Jul 2006) ISSN: 0009-9147 [Print] England
PMID16709624 (Publication Type: Journal Article, Review)
Chemical References
  • Actins
  • Biomarkers
  • Vitamin D-Binding Protein
Topics
  • Actins (physiology)
  • Acute Kidney Injury (metabolism, physiopathology)
  • Biomarkers (analysis)
  • Humans
  • Immunoassay
  • Sepsis (metabolism, physiopathology)
  • Vitamin D-Binding Protein (analysis, genetics, physiology)
  • Wounds and Injuries (metabolism, physiopathology)

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