[Comparative assessment of combined therapy of neurogenic hyperactivity of detrusor in patients with Parkinson's disease].

Abstract

We studied clinical characteristics of voiding disorders to improve treatment results in patients with Parkinson's disease (PD) in 64 PD patients (28 women and 36 men aged 45 to 76 years, mean age 62.5 +/- 9.4 years). Duration of PD was 8.0 +/- 3.4 years, history of voiding disorders--2.1 +/- 0.8 years. Hyperactive urinary bladder was the cause of voiding disorders in all the patients. The examinees have undergone physical examination, microscopic and cultural examination of the urine, ultrasound investigation of the kidneys, urinary bladder and prostate with determination of residual urine, urodynamic examination of the lower urinary tracts. All the patients were divided into four groups. Group 1 of 10 patients received antiparkinsonian therapy which corrected voiding disorders. Group 2 (n = 26) received tolterodin in a dose 4 mg/day, group 3 (n = 14) received oxibutinin in a dose 5 mg/day, group 4 (n = 14) were treated with trospium chloride in a dose 30 mg/day. Thus, initial correction of antiparkinsonian therapy was made in 64 patients, after this correction voiding disorders reduced in 10 patients and no further treatment was needed. Voiding disorders reduced in all 3 groups of patients given the drugs. Cystometric capacity of the bladder increased in all 4 groups from 155 (86-450) ml to 220 (105-530) ml, on the average, and unstable contractions of the urinary bladder decreased from 3.1 (1-8) to 1.6 (0-5). Quality of life in the examinees improved considerably. The data obtained evidence for M-cholino-blockers efficacy in PD patients with unstable detrusor after correction of antiparkinsonean therapy. Two-month course of tolterodin, oxibutinin and trospium chloride significantly reduced symptoms of urination disorders.

• Authors: O B Loran, N V Fedorova, D A Mazurenko, E V Khitarishvili
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) 2006 Mar-Apr Issue 2 Pg. 37-9, 41 ISSN: 1728-2985 [Print] Russia (Federation)
• PMID: 16708587 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiparkinson Agents
• Muscarinic Antagonists

Topics

• Aged
• Antiparkinson Agents (therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Muscarinic Antagonists (therapeutic use)
• Parkinson Disease (complications, drug therapy)
• Quality of Life
• Treatment Outcome
• Urinary Bladder, Neurogenic (complications, drug therapy)
• Urinary Incontinence (complications, drug therapy)