Abstract | BACKGROUND: This study aimed to evaluate the optimal timing of preemptive analgesia with bupivacaine peritoneal instillation in a prospective, randomized, double-blind, placebo-controlled trial. METHODS: RESULTS: Significantly lower visual analog scores were observed in group A versus groups C and B versus group D during the initial 48 and 24 h, respectively. The patients in group A versus group B reported significantly lower pain at 4 h (p < 0.001) and 8 h (p = 0.003) postoperatively, but the difference was not significant after 12, 24, and 48 h. None of the group A patients reported shoulder tip pain, whereas it was reported by 3 patients in group B, 6 patients in group C, and 7 patients in group D (p < 0.01). The latency of nurse-controlled analgesia activation was 426.8 +/-57.2 min in group A, as compared with 307 +/- 39.8 min in group B, 109.3 +/- 51 min in group C, and 109 +/- 46.5 min in group D (p < 0.001). A significantly lower analgesia request rate was observed in group A versus C, as compared with group B versus D, throughout the entire study period (p < 0.05). CONCLUSIONS:
|
Authors | M Barczyński, A Konturek, R M Herman |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 20
Issue 7
Pg. 1088-93
(Jul 2006)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 16703434
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Anesthetics, Local
- Bupivacaine
|
Topics |
- Analgesia
- Anesthetics, Local
(administration & dosage)
- Bupivacaine
(administration & dosage)
- Cholecystectomy, Laparoscopic
(adverse effects)
- Double-Blind Method
- Female
- Humans
- Instillation, Drug
- Male
- Middle Aged
- Pain, Postoperative
(prevention & control)
- Pneumoperitoneum, Artificial
(adverse effects)
- Prospective Studies
- Time Factors
|