Abstract | BACKGROUND: METHODS: RESULTS: In the Sulfamylon-open dressing group, the DNA FSR was 1.3 +/- 0.6%/day, the protein FSR was 8.0 +/- 3.5%/day, and the net protein deposition (FSR - FBR) was -0.3 +/- 3.7%/day. These values were lower (P < .01 to .05) than the corresponding values in the control group ( DNA FSR: 2.9 +/- 0.9%/day; protein FSR: 20.5 +/- 8.4%/day; net protein deposition: 7.9 +/- 6.0%/day). Sulfamylon cream selectively inhibited DNA FSR from the de novo base synthesis pathway (2.3 +/- 1.2 vs 0.8 +/- 0.5%/day, P < .05 vs control). With the occlusive dressing Sulfamylon cream did not decrease wound DNA FSR due to a stimulation of the base salvage pathway, but still decreased protein FSR (11.5 +/- 5.1%/day, P < .05 vs control). Histologic slides indicated that Sulfamylon cream inhibited re-epithelialization, collagen formation, and angiogenesis in the wound. CONCLUSIONS: Topical Sulfamylon cream application inhibited DNA and protein synthesis in the wound, which would be expected to retard the healing process.
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Authors | Xiao-Jun Zhang, John P Heggers, David L Chinkes, Steven E Wolf, Hal K Hawkins, Robert R Wolfe |
Journal | Surgery
(Surgery)
Vol. 139
Issue 5
Pg. 633-9
(May 2006)
ISSN: 0039-6060 [Print] United States |
PMID | 16701096
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amino Acids
- Anti-Infective Agents, Local
- Mafenide
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Topics |
- Administration, Topical
- Amino Acids
(blood)
- Animals
- Anti-Infective Agents, Local
(administration & dosage, therapeutic use)
- Bandages
- Dermatologic Surgical Procedures
- Living Donors
- Mafenide
(administration & dosage, therapeutic use)
- Male
- Models, Animal
- Occlusive Dressings
- Rabbits
- Skin
(injuries, pathology)
- Wounds and Injuries
(drug therapy)
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