[A case of hepatic metastases of sigmoid colon cancer which completely responded to systemic l-leucovorin/5-FU therapy and oral LV/UFT combination therapy].

Abstract

A 73-year-old man was admitted for sigmoid colon cancer with multiple hepatic metastases. The patient underwent a sigmoidectomy only, because of bronchial asthma. Then, l-leucovorin (375 mg/body) and 5-FU (750 mg/body) were injected every week. After 2 cycles (1 cycle: 6 weeks of therapy followed by a 2-week treatment break), CT scanning showed almost a complete response, without side effects such as nausea, vomiting, diarrhea and bone marrow suppression. Then, oral administration of LV and UFT was started (LV 75 mg/body/day, UFT 450 mg/body/day. After 2 weeks of therapy, there was a 1-week treatment break), and 2 years after operation this therapy was stopped because the complete response on CT scanning continued.

• Authors: Yoshimasa Ishii, Masayasu Takahashi, Teruhide Ishigame, Hirokazu Okayama
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 33 Issue 5 Pg. 675-8 (May 2006) ISSN: 0385-0684 [Print] Japan
• PMID: 16685171 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• UFT(R) drug
• Tegafur
• Uracil
• Leucovorin
• Fluorouracil

Topics

• Administration, Oral
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Drug Administration Schedule
• Drug Combinations
• Fluorouracil (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Liver Neoplasms (drug therapy, secondary)
• Male
• Sigmoid Neoplasms (drug therapy, pathology, surgery)
• Tegafur (administration & dosage)
• Uracil (administration & dosage)