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Combination of narrow band UVB and topical calcipotriol for the treatment of vitiligo.

AbstractBACKGROUND:
Narrow band ultraviolet B (NB-UVB) phototherapy has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been claimed to be effective, either as monotherapy or as a part of combination therapies.
OBJECTIVE:
The aim of the present study was to compare the clinical efficacy of NB-UVB and NB-UVB plus topical calcipotriol in the treatment of vitiligo.
METHODS:
NB-UVB treatment was given to 24 patients with generalized vitiligo three times weekly. Topical calcipotriol cream was only applied to the lesions located on the right side of the body. Treatment was continued for 6 months. Treatment efficacy was evaluated by determining the average response rates of the lesions at 3-month intervals.
RESULTS:
The average response rates of patients receiving combination of NB-UVB plus calcipotriol and NB-UVB alone were 51 +/- 19.6% and 39 +/- 18.9%, respectively. The median cumulative UVB dose and number of UVB exposures for initial repigmentation were 6345 mj/cm(2) (range; 2930-30980) and 18 (range; 12-67) for the combination therapy, and 8867.5 mj/cm(2) (range; 2500-30980) and 24 (range; 15-67) for the narrow band UVB therapy, respectively.
CONCLUSIONS:
These findings indicate that concurrent topical calcipotriol potentates the efficacy of NB-UVB in the treatment of vitiligo. This combination not only provides earlier pigmentation with lower total UVB dosage and less adverse UVB effects, but also reduces the duration and cost of treatment as well.
AuthorsE O Goktas, F Aydin, N Senturk, M T Canturk, A Y Turanli
JournalJournal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 20 Issue 5 Pg. 553-7 (May 2006) ISSN: 0926-9959 [Print] England
PMID16684283 (Publication Type: Journal Article)
Chemical References
  • Dermatologic Agents
  • calcipotriene
  • Calcitriol
Topics
  • Adolescent
  • Adult
  • Calcitriol (analogs & derivatives, therapeutic use)
  • Combined Modality Therapy
  • Dermatologic Agents (therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome
  • Ultraviolet Therapy (methods)
  • Vitiligo (drug therapy, radiotherapy)

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