First case of ivermectin-induced severe hepatitis.

Abstract

Loiasis, caused by the filarial parasite Loa loa, is endemic in West and Central Africa. Ivermectin has been shown to be an effective treatment of loiasis. We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin. Liver biopsy showed intralobular inflammatory infiltrates, confluent necrosis and apoptosis, compatible with drug-induced liver disease. To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literature.

• Authors: Olivia Veit, Bernhard Beck, Michael Steuerwald, Christoph Hatz
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) Vol. 100 Issue 8 Pg. 795-7 (Aug 2006) ISSN: 0035-9203 [Print] England
• PMID: 16682062 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiparasitic Agents
• Ivermectin

Topics

• Adult
• Animals
• Antiparasitic Agents (adverse effects)
• Cameroon
• Chemical and Drug Induced Liver Injury (etiology)
• Female
• Humans
• Ivermectin (adverse effects)
• Loa (isolation & purification)
• Loiasis (drug therapy)
• Microfilariae (isolation & purification)