Abstract | BACKGROUND: Saliva can be used as a diagnostic fluid in medicine. Components of saliva proposed as disease markers include enzymes ( alkaline phosphatase, esterase, glucuronidase, aminopeptidase), immunoglobulins ( IgA, IgG), and hormones ( steroid hormones). Many of these salivary components appeared to be useful biochemical markers of the evolution of periodontal disease, for which salivary analysis can offer a cost-effective approach for monitoring the disease. The salivary components proposed as markers for periodontal disease activity are aspartate aminotransferase (AST), alkaline phosphatase (ALP), aminopeptidases, and glucuronidases. The purpose of our study was to illustrate the influence of periodontal disease on the level of salivary AST, alanine aminotransferase (ALT) and ALP. METHODS: All clinical periodontal examinations were performed by the same periodontist. All patients included in the study presented a probing depth >5 mm, bleeding on probing and alveolar bone loss >40%. Salivary AST, ALT and ALP activities were measured using DiaSys analysis kits from Diagnostic Systems. The methods were adapted for saliva. RESULTS: Salivary AST activity in patients with periodontal disease was significantly increased (p<0.01) (median 81.75+/-23 U/L) compared with controls (15.25+/-10.5 U/L). Salivary ALT activity was not significantly modified in saliva from patients with periodontal disease compared with the control group. Our results showed a significant (p<0.01) increase in salivary ALP activity (34.38+/-1.5 U/L) in patients with periodontal disease compared with controls (6.6+/-4.2 U/L). CONCLUSIONS:
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Authors | Alexandra Totan, Maria Greabu, Cosmin Totan, Tudor Spinu |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 44
Issue 5
Pg. 612-5
( 2006)
ISSN: 1434-6621 [Print] Germany |
PMID | 16681433
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Aspartate Aminotransferases
- Alanine Transaminase
- Alkaline Phosphatase
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Topics |
- Adult
- Alanine Transaminase
(metabolism)
- Alkaline Phosphatase
(analysis)
- Aspartate Aminotransferases
(metabolism)
- Biomarkers
(metabolism)
- Case-Control Studies
- Clinical Enzyme Tests
- Humans
- Middle Aged
- Periodontal Diseases
(diagnosis, metabolism)
- Saliva
(metabolism)
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