Abstract | OBJECTIVE: To investigate the clinical efficacy and safety of Acticoat (nanocrystalline silver dressing) for the treatment of residual burn wounds. METHODS: Ninety-eight patients with 166 residual burn wounds were enrolled in the multi-center randomized clinical trials. In addition to the routine treatment, Acticoat was applied onto the wounds of the trial group once a day if there was much exudation from the wound, or the dressing change was made every other two days when the wounds were clean. Silver sulfadiazine (SD-Ag) was used in the control group of patients. The healing time was observed up to 20 days. The healing rate on the 15th day after treatment was taken as the percentage of healing. RESULTS: The average healing time was (12 +/- 5) days after the application of Acticoat, which was significantly shorter than that in control wounds with SD-Ag (16 +/- 6) days, (P = 0.005 < 0.01). The total effective rate of the wounds for trial was 97.05%, which was higher than that in control (94.17%) group, but there was no statistically significant difference. The bacterial clearing rate of the Acticoat group on the 6th and 12th post treatment day was 21.7% and 43.5% respectively, which was significantly higher than that in control group. No side-effect was observed in the two groups during the study. CONCLUSION:
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Authors | Xiao-lu Li, Yue-sheng Huang, Yi-zhi Peng, Zhen-jiang Liao, Guo-an Zhang, Qun Liu, Jin Tang, Xu-sheng Liu, Qi-zhi Luo |
Journal | Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
(Zhonghua Shao Shang Za Zhi)
Vol. 22
Issue 1
Pg. 15-8
(Feb 2006)
ISSN: 1009-2587 [Print] China |
PMID | 16680954
(Publication Type: Case Reports, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Acticoat
- Polyesters
- Polyethylenes
- Silver Sulfadiazine
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Topics |
- Adolescent
- Adult
- Aged
- Bandages
- Burns
(therapy)
- Humans
- Male
- Middle Aged
- Nanoparticles
- Polyesters
(therapeutic use)
- Polyethylenes
(therapeutic use)
- Silver Sulfadiazine
(therapeutic use)
- Single-Blind Method
- Skin, Artificial
- Wound Healing
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