Abstract | OBJECTIVE: METHODS: RESULTS: The antibody recognized epitopes present in mouse plasma and reduced the plasma level of oxidized LDL by 34%. Antibody treatment inhibited injury-induced restrictive vascular remodelling but did not influence the size of the neointima. Atherosclerosis in the uninjured contra lateral carotid artery was determined by computerized image analysis and the mean plaque area in animals given control IgG1 was 7608+/-10,336 micro m(2). In contrast, essentially no plaques were present in animals treated with the 2D03 antibody (397+/-235 micro m(2), P<0.01 versus control IgG1). CONCLUSIONS:
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Authors | Asa Ström, Gunilla Nordin Fredrikson, Alexandru Schiopu, Irena Ljungcrantz, Ingrid Söderberg, Bo Jansson, Roland Carlsson, Anna Hultgårdh-Nilsson, Jan Nilsson |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 190
Issue 2
Pg. 298-305
(Feb 2007)
ISSN: 0021-9150 [Print] Ireland |
PMID | 16677655
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aldehydes
- Antibodies
- Apolipoprotein B-100
- Immunoglobulin G
- Receptors, LDL
- Recombinant Proteins
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Topics |
- Aldehydes
- Animals
- Antibodies
(therapeutic use)
- Apolipoprotein B-100
(genetics, immunology)
- Carotid Arteries
(physiology)
- Carotid Artery Diseases
(therapy)
- Humans
- Immunoglobulin G
(metabolism)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Receptors, LDL
(deficiency, immunology)
- Recombinant Proteins
(therapeutic use)
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