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Lethal photosensitization and guided bone regeneration in treatment of peri-implantitis: an experimental study in dogs.

Abstract
The purpose of this study was to evaluate the effect of lethal photosensitization and guided bone regeneration (GBR) on the treatment of ligature-induced peri-implantitis in different implant surfaces. The treatment outcome was evaluated by clinical and histometric methods. A total of 40 dental implants with four different surface coatings (10 commercially pure titanium surface (cpTi); 10 titanium plasma-sprayed (TPS); 10 acid-etched surface; 10 surface-oxide sandblasted) were inserted into five mongrel dogs. After 3 months, the animals with ligature-induced peri-implantitis were subjected to surgical treatment using a split-mouth design. The controls were treated by debridment and GBR, while the test side received an additional therapy with photosensitization, using a GaAlAs diode laser, with a wavelength of 830 nm and a power output of 50 mW for 80 s (4 J/cm2), and sensitized toluidine blue O (100 microg/ml). The animals were sacrificed 5 months after therapy. The control sites presented an earlier exposition of the membranes on all coating surfaces, while the test group presented a higher bone height gain. Re-osseointegration ranged between 41.9% for the cpTi surface and 31.19% for the TPS surface in the test sites; however differences were not achieved between the surfaces. The lethal photosensitization associated with GBR allowed for better re-osseointegration at the area adjacent to the peri-implant defect regardless of the implant surface.
AuthorsJamil Awad Shibli, Marilia Compagnoni Martins, Fernando Salimon Ribeiro, Valdir Gouveia Garcia, Francisco Humberto Nociti Jr, Elcio Marcantonio Jr
JournalClinical oral implants research (Clin Oral Implants Res) Vol. 17 Issue 3 Pg. 273-81 (Jun 2006) ISSN: 0905-7161 [Print] Denmark
PMID16672022 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Coated Materials, Biocompatible
  • Dental Implants
  • Dental Materials
  • Photosensitizing Agents
  • Tolonium Chloride
  • Titanium
Topics
  • Acid Etching, Dental
  • Air Abrasion, Dental
  • Animals
  • Bone Regeneration (physiology)
  • Coated Materials, Biocompatible (chemistry)
  • Debridement
  • Dental Implants
  • Dental Materials (chemistry)
  • Dental Prosthesis Design
  • Dogs
  • Guided Tissue Regeneration, Periodontal (methods)
  • Laser Therapy
  • Male
  • Mandible (pathology, surgery)
  • Osseointegration (physiology)
  • Periodontitis (drug therapy, pathology, surgery)
  • Photochemotherapy
  • Photosensitizing Agents (therapeutic use)
  • Random Allocation
  • Surface Properties
  • Titanium (chemistry)
  • Tolonium Chloride (therapeutic use)
  • Treatment Outcome

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