Cerebral perfusion response to hyperoxia.

Abstract

Graded levels of supplemental inspired oxygen were investigated for their viability as a noninvasive method of obtaining intravascular magnetic resonance image contrast. Administered hyperoxia has been shown to be effective as a blood oxygenation level-dependent contrast agent for magnetic resonance imaging (MRI); however, it is known that high levels of inspired fraction of oxygen result in regionally decreased perfusion in the brain potentially confounding the possibility of using hyperoxia as a means of measuring blood flow and volume. Although the effects of hypoxia on blood flow have been extensively studied, the hyperoxic regime between normoxia and 100% inspired oxygen has been only intermittently studied. Subjects were studied at four levels of hyperoxia induced during a single session while perfusion was measured using arterial spin labelling MRI. Reductions in regional perfusion of grey matter were found to occur even at moderate levels of hyperoxia; however, perfusion changes at all oxygen levels were relatively mild (less than 10%) supporting the viability of hyperoxia-induced contrast.

• Authors: Daniel P Bulte, Peter A Chiarelli, Richard G Wise, Peter Jezzard
• Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 27 Issue 1 Pg. 69-75 (Jan 2007) ISSN: 0271-678X [Print] United States
• PMID: 16670698 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Spin Labels
• Carbon Dioxide
• Oxygen

Topics

• Adult
• Algorithms
• Carbon Dioxide (blood)
• Cerebrovascular Circulation (physiology)
• Female
• Humans
• Hyperoxia (physiopathology)
• Kinetics
• Magnetic Resonance Imaging
• Male
• Models, Statistical
• Oxygen (blood)
• Spin Labels