Anticonvulsive efficacy of flumazenil in the electroinduced seizures in the rabbit.

Abstract

The anticonvulsive efficacy of flumazenil, a specific antagonist of the ligands of the benzodiazepine receptor, was studied in the experimental seizures induced by electrical stimulation of corpus Amygdaloideum and Cornu Ammonis dorsale of the hippocampus in rabbits. In the amygdaloid seizure model flumazenil raised the threshold and/or reduced the afterdischarge duration. Results observed in the seizures induced by stimulation of hippocampus were less consistent. Possible explanations are discussed.

• Authors: P Bo, C Dallocchio, R Turrini, F Savoldi
• Journal: Bollettino della Societa italiana di biologia sperimentale (Boll Soc Ital Biol Sper) Vol. 67 Issue 6 Pg. 585-91 (Jun 1991) ISSN: 0037-8771 [Print] Italy
• PMID: 1666514 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Receptors, GABA-A
• Flumazenil

Topics

• Acute Disease
• Amygdala (physiopathology)
• Animals
• Anticonvulsants (pharmacology, therapeutic use)
• Electric Stimulation (adverse effects)
• Electroencephalography
• Flumazenil (pharmacology, therapeutic use)
• Hippocampus (physiopathology)
• Rabbits
• Receptors, GABA-A (drug effects)
• Seizures (drug therapy, etiology, physiopathology, prevention & control)