[Diagnosis of fetal virus infections by in situ hybridization].

Abstract

Non-radioactive in situ hybridization of formalin-fixed paraffin-embedded placental and foetal tissue, using virus-specific DNA or RNA probes, may be helpful for the diagnosis of foetal virus infection causing foetal hydrops, granulomatous placentitis and abortion. We present four cases of intrauterine CMV-, Parvo-B19- and Varicella-Zoster virus infection, in which this diagnostic method established detection of the virus.

• Authors: Y Mehraein, H Rehder, H G Draeger, U G Froster-Iskenius, E Schwinger, W Holzgreve
• Journal: Geburtshilfe und Frauenheilkunde (Geburtshilfe Frauenheilkd) Vol. 51 Issue 12 Pg. 984-9 (Dec 1991) ISSN: 0016-5751 [Print] Germany
• Vernacular Title: Die Diagnostik fetaler Virusinfektionen durch In-situ-Hybridisierung.
• PMID: 1665465 (Publication Type: Case Reports, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA Probes
• RNA Probes

Topics

• Adult
• Chickenpox (pathology)
• Cytomegalovirus (isolation & purification)
• Cytomegalovirus Infections (pathology)
• DNA Probes
• Endothelium, Vascular (pathology)
• Female
• Fetal Diseases (pathology)
• Herpesvirus 3, Human (isolation & purification)
• Humans
• Inclusion Bodies, Viral (ultrastructure)
• Infant, Newborn
• Kidney (pathology)
• Male
• Pancreas (pathology)
• Parvoviridae Infections (pathology)
• Parvovirus B19, Human (isolation & purification)
• Placenta (pathology)
• Pregnancy
• Pregnancy Complications, Infectious (pathology)
• Prenatal Diagnosis
• RNA Probes
• Virus Diseases (pathology)