Abstract |
We report widely disseminated molluscum contagiosum that occurred in a 9-year-old boy secondary to hyperimmunoglobulin E syndrome, a primary immunodeficiency disorder. Cutaneous examination revealed numerous, widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes. They were distributed throughout the perineal and gluteal areas and bilaterally over his lower limbs. A biopsy specimen from his skin lesion demonstrated lobulated epidermal growth that consisted of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Many treatments for his skin lesions were ineffective, including physical destruction or manual extrusion of the lesions; cryotherapy; curettage; and topical therapies with phenol, trichloroacetic acid, and imiquimod. The patient was treated successfully with subcutaneous interferon-alpha for 6 months without any adverse effect.
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Authors | Sara Sebnem Kilic, Fatih Kilicbay |
Journal | Pediatrics
(Pediatrics)
Vol. 117
Issue 6
Pg. e1253-1255
(Jun 2006)
ISSN: 1098-4275 [Electronic] United States |
PMID | 16651279
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antiviral Agents
- Interferon-alpha
|
Topics |
- Antiviral Agents
(therapeutic use)
- Child
- Humans
- Interferon-alpha
(therapeutic use)
- Job Syndrome
(complications)
- Male
- Molluscum Contagiosum
(drug therapy, etiology)
- Remission Induction
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