Abstract | OBJECTIVE: METHOD: The authors investigated cortical 5-HT2A receptor binding in eight adults with Asperger's syndrome and in 10 healthy comparison subjects with single photon emission computed tomography and the selective 5-HT2A receptor ligand 123I iodinated 4-amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide (123I-5-I-R91150). RESULTS: People with Asperger's syndrome had a significant reduction in cortical 5-HT2A receptor binding in the total, anterior, and posterior cingulate; bilaterally in the frontal and superior temporal lobes; and in the left parietal lobe. Also, reduced receptor binding was significantly related to abnormal social communication. CONCLUSIONS: The authors' findings suggest that adults with Asperger's syndrome have abnormalities in cortical 5-HT2A receptor density and that this deficit may underlie some clinical symptoms.
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Authors | Declan G M Murphy, Eileen Daly, Nicole Schmitz, Fiona Toal, Keiran Murphy, Sarah Curran, Kjell Erlandsson, Jos Eersels, Robert Kerwin, Peter Ell, Michael Travis |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 163
Issue 5
Pg. 934-6
(May 2006)
ISSN: 0002-953X [Print] United States |
PMID | 16648340
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Iodine Radioisotopes
- Piperidines
- R 91150
- Receptor, Serotonin, 5-HT2A
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Topics |
- Adult
- Asperger Syndrome
(diagnostic imaging, metabolism, psychology)
- Cerebral Cortex
(diagnostic imaging, metabolism)
- Communication
- Functional Laterality
- Gyrus Cinguli
(diagnostic imaging, metabolism)
- Humans
- Iodine Radioisotopes
- Male
- Parietal Lobe
(diagnostic imaging, metabolism)
- Piperidines
- Psychiatric Status Rating Scales
- Receptor, Serotonin, 5-HT2A
(metabolism)
- Social Behavior
- Temporal Lobe
(diagnostic imaging, metabolism)
- Tomography, Emission-Computed, Single-Photon
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