Abstract | BACKGROUND: Postinfarct remodeled myocardium exhibits numerous structural and biochemical alterations. So far, it is unknown whether postconditioning elicited by volatile anesthetics can also provide protection in the remodeled myocardium. METHODS: RESULTS: CONCLUSIONS:
Infarct-remodeled myocardium is receptive to protection by isoflurane postconditioning via protein kinase B/Akt signaling. This is the first time to demonstrate that anesthetic postconditioning retains its marked protection in diseased myocardium.
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Authors | Jianhua Feng, Gregor Fischer, Eliana Lucchinetti, Min Zhu, Lukas Bestmann, David Jegger, Margarete Arras, Thomas Pasch, Jean-Claude Perriard, Marcus C Schaub, Michael Zaugg |
Journal | Anesthesiology
(Anesthesiology)
Vol. 104
Issue 5
Pg. 1004-14
(May 2006)
ISSN: 0003-3022 [Print] United States |
PMID | 16645453
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Inhalation
- Cardiotonic Agents
- RNA, Messenger
- Isoflurane
- Oncogene Protein v-akt
- Proto-Oncogene Proteins c-akt
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Topics |
- Anesthetics, Inhalation
(pharmacology)
- Animals
- Blotting, Western
- Cardiotonic Agents
- Hemodynamics
(drug effects)
- In Vitro Techniques
- Isoflurane
(pharmacology)
- Male
- Myocardium
(ultrastructure)
- Oncogene Protein v-akt
(physiology)
- Proto-Oncogene Proteins c-akt
(physiology)
- RNA, Messenger
(biosynthesis, isolation & purification)
- Rats
- Rats, Wistar
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
(drug effects)
- Ventricular Remodeling
(drug effects)
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