[Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors].

Abstract

BACKGROUND:

To investigate variant genotyping of CCR2-64I, SDF1-3'A and CCR5Delta32 in HIV-1 infected Chinese Long-term nonprogressors and to study their association with disease progression.

METHODS:

The genotypes of CCR2-64I, SDF1-3'A and CCR5Delta32 were detected by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) assay in seventeen HIV-1 infected Chinese Long-term nonprogressors (LTNPs) and thirty-nine Chinese typical progressors (TPs).

RESULTS:

The frequency of CCR2-64I and SDF1-3'A in LTNPs are 50% and 62.5%, higher than those (23.08% and 33.33%) in TPs. Only one heterozygous CCR5 mutant was detected in LTNPs, and no CCR5 mutant in TPs.

CONCLUSION:

Variant genotyping of CCR2-64ISDF1-3'A and CCR5Delta32 may be protective factors for delaying disease progression in HIV-1 infected Chinese LTNPs.

• Authors: Shu-xiang Wang, Hong Shang, Xiao-xu Han, Zi-ning Zhang, Ya-nan Wang, Min Zhang, Yong-jun Jiang, Jing Liu, Yan-li Su
• Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi) Vol. 20 Issue 1 Pg. 16-9 (Mar 2006) ISSN: 1003-9279 [Print] China
• PMID: 16642210 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chemokine CXCL12
• Receptors, CCR2
• Receptors, CCR5
• Receptors, HIV

Topics

• Chemokine CXCL12 (genetics)
• China
• Gene Frequency
• Genotype
• HIV Infections (genetics, pathology, virology)
• HIV Long-Term Survivors
• HIV-1 (physiology)
• Host-Pathogen Interactions
• Humans
• Mutation
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Receptors, CCR2 (genetics)
• Receptors, CCR5 (genetics)
• Receptors, HIV (genetics)