Abstract |
The study was undertaken to examine myocardial morphological alterations in mice treated with T-activin in different periods of viral myocarditis. Two-month BALB/C mice of both sexes were used in the experiments, which were intraperitoneally given 0.2 ml Coxsackie B1 virus in a titer of 10(-3)-10(-7) D50 ml. The material was taken 3, 5, 7, 9, 15, and 30 days following infection. Intact mice and animals given culture fluid were applied as controls. T-activin was subcutaneously injected in a dose of 0.2 ml at the rate of 0.01 mg per kg body weight on day 5 after virus infection for 5 days. The predominance of an alterative component of inflammation (dystrophic, necrobiotic and necrotic changes) over proliferative processes was ascertained to be common to all periods of infection. T-activin administration attenuated myocardial damage.
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Authors | N N Kipshidze, V G Tsyplenkova, V S Zhdanov, M M Dzhaparidze |
Journal | Kardiologiia
(Kardiologiia)
Vol. 31
Issue 7
Pg. 61-5
(Jul 1991)
ISSN: 0022-9040 [Print] Russia (Federation) |
Vernacular Title | Morfologicheskoe izuchenie miokarda mysheĭ, infitsirovannykh virusom Koksaki B1, na fone lecheniia immunomoduliruiushchim preparatom T-aktivinom. |
PMID | 1664006
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Adjuvants, Immunologic
- Peptides
- Thymus Extracts
- T-activin
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Topics |
- Adjuvants, Immunologic
(therapeutic use)
- Animals
- Coxsackievirus Infections
(drug therapy, immunology, pathology)
- Disease Models, Animal
- Enterovirus B, Human
- Female
- Male
- Mice
- Mice, Inbred BALB C
- Microscopy, Electron
- Myocarditis
(drug therapy, immunology, pathology)
- Myocardium
(pathology, ultrastructure)
- Peptides
(therapeutic use)
- Thymus Extracts
(therapeutic use)
- Time Factors
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