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[Morphological study of the myocardium of mice infected with Coxsackie B1 virus during the treatment with an immunomodulating drug T-activin].

Abstract
The study was undertaken to examine myocardial morphological alterations in mice treated with T-activin in different periods of viral myocarditis. Two-month BALB/C mice of both sexes were used in the experiments, which were intraperitoneally given 0.2 ml Coxsackie B1 virus in a titer of 10(-3)-10(-7) D50 ml. The material was taken 3, 5, 7, 9, 15, and 30 days following infection. Intact mice and animals given culture fluid were applied as controls. T-activin was subcutaneously injected in a dose of 0.2 ml at the rate of 0.01 mg per kg body weight on day 5 after virus infection for 5 days. The predominance of an alterative component of inflammation (dystrophic, necrobiotic and necrotic changes) over proliferative processes was ascertained to be common to all periods of infection. T-activin administration attenuated myocardial damage.
AuthorsN N Kipshidze, V G Tsyplenkova, V S Zhdanov, M M Dzhaparidze
JournalKardiologiia (Kardiologiia) Vol. 31 Issue 7 Pg. 61-5 (Jul 1991) ISSN: 0022-9040 [Print] Russia (Federation)
Vernacular TitleMorfologicheskoe izuchenie miokarda mysheĭ, infitsirovannykh virusom Koksaki B1, na fone lecheniia immunomoduliruiushchim preparatom T-aktivinom.
PMID1664006 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • Peptides
  • Thymus Extracts
  • T-activin
Topics
  • Adjuvants, Immunologic (therapeutic use)
  • Animals
  • Coxsackievirus Infections (drug therapy, immunology, pathology)
  • Disease Models, Animal
  • Enterovirus B, Human
  • Female
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Microscopy, Electron
  • Myocarditis (drug therapy, immunology, pathology)
  • Myocardium (pathology, ultrastructure)
  • Peptides (therapeutic use)
  • Thymus Extracts (therapeutic use)
  • Time Factors

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