Whole blood cardioplegia (minicardioplegia) reduces myocardial edema after ischemic injury and cardiopulmonary bypass.

Abstract

While blood:crystalloid cardioplegia is the clinical standard for patients undergoing cardiopulmonary bypass (CPB), it has been postulated that whole blood minicardioplegia may benefit the severely injured heart by reducing cardioplegic volume, thereby reducing myocardial edema. To test this hypothesis, we compared the cardioprotection of a popular 4:1 blood:crystalloid cardioplegia to whole blood minicardioplegia (WB) in a porcine model of acute myocardial ischemia. Yorkshire pigs (n = 20) were placed on atriofemoral bypass and subjected to 30 minutes of global normothermic ischemia. Animals were randomized to receive either 4:1 cold cardioplegia (n = 10) or WB cold cardioplegia (n = 10) delivered antegrade continuously for 90 minutes. Baseline (BL) echocardiographic determination of left ventricular mass (LVM) was compared within groups for cardiac edema (%) measured by histologic morphometrics. All (100%) animals receiving WB were successfully weaned off CPB, whereas only 40% of animals receiving 4:1 were successfully weaned off CPB. Cardiac edema percentage (p < .004) and LVM (p < .05) were significantly decreased in the WB group compared with 4:1. WB cardioplegia increases the number of hearts successfully weaned from CPB and decreases cardiac edema in our porcine model of acute myocardial ischemia. This finding implies whole blood cardioplegia may be more protective in a select group of patients undergoing extended CPB time by decreasing myocardial edema.

• Authors: Ulysses G McCann 2nd, Charles J Lutz, Anthony L Picone, Bruce Searles, Louis A Gatto, Karikehalli A Dilip, Gary F Nieman
• Journal: The journal of extra-corporeal technology (J Extra Corpor Technol) Vol. 38 Issue 1 Pg. 14-21 (Mar 2006) ISSN: 0022-1058 [Print] United States
• PMID: 16637518 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cardioplegic Solutions

Topics

• Acute Disease
• Animals
• Cardiomyopathies (prevention & control)
• Cardioplegic Solutions (therapeutic use)
• Cardiopulmonary Bypass (adverse effects)
• Edema (prevention & control)
• Edema, Cardiac (prevention & control)
• Heart Arrest, Induced (methods)
• Myocardial Ischemia (complications, physiopathology)
• Myocardial Reperfusion (methods)
• Myocardial Revascularization (methods)
• Swine