Location of focal vasospasm provoked by ergonovine maleate within coronary arteries in patients with vasospastic angina pectoris.

Abstract

This study examined whether coronary focal vasospasm occurs in a nonuniform distribution within the coronary tree and whether a longitudinal plaque distribution pattern is present in patients with vasospastic angina using 3-dimensional intravascular ultrasound analysis. Of 121 patients with clinically suspected angina without fixed stenosis in the coronary arteries, vasospasm was provoked in 82 patients with 92 lesions (42 focal, 50 diffuse) by intravenous ergonovine maleate injection. Most focal vasospasms occurred in the proximal third of the coronary arteries (proximal 28, mid 8, distal 6, p <0.01), corresponding to the historical high-risk zones for acute coronary occlusion. More plaque burden also existed in the proximal third of the coronary arteries in patients with focal vasospasm.

• Authors: Tomomi Koizumi, Masaki Yokoyama, Susumu Namikawa, Nehiro Kuriyama, Mizuo Nameki, Takashi Nakayama, Hideaki Kaneda, Krishnankutty Sudhir, Paul G Yock, Nobuyuki Komiyama, Peter J Fitzgerald
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 97 Issue 9 Pg. 1322-5 (May 01 2006) ISSN: 0002-9149 [Print] United States
• PMID: 16635604 (Publication Type: Journal Article)

Chemical References

• Vasoconstrictor Agents
• Ergonovine

Topics

• Angina Pectoris (diagnostic imaging)
• Coronary Angiography
• Coronary Artery Disease (diagnostic imaging)
• Coronary Vasospasm (chemically induced, diagnostic imaging)
• Coronary Vessels (diagnostic imaging)
• Electrocardiography
• Ergonovine
• Female
• Humans
• Imaging, Three-Dimensional
• Injections, Intravenous
• Male
• Middle Aged
• Ultrasonography, Interventional
• Vasoconstrictor Agents